Health News Update: Aging is Driven by Inflammation

Mark Smith • June 23, 2025

Health News Update: Aging is Driven by Inflammation                         6.23.25

Hello again, everyone: Here you will view some links in the scientific literature showing that regardless of age, inflammation drives accelerated aging and the creation of all causes of death and illness…and it much worse when we are older. Do you think it would be a good idea to start to manage your inflammatory burden at a younger age?

Abstract: Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging." Inflammaging is a highly significant risk factor for both morbidity (illness) and mortality (death) in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis.   https://pubmed.ncbi.nlm.nih.gov/24833586/

Abstract: Aging is the greatest risk factor for the development of chronic diseases such as arthritis, type 2 diabetes, cardiovascular disease, kidney disease, Alzheimer's disease, macular degeneration, frailty, and certain forms of cancers. It is widely regarded that chronic inflammation may be a common link in all these age-related diseases. This raises the question, can one alter the course of aging and potentially slow the development of all chronic diseases by manipulating the mechanisms that cause age-related inflammation? https://pmc.ncbi.nlm.nih.gov/articles/PMC4400872/

It turns out that one of the primary drivers of inflammation is activation of inflammasome biology…a part of the immune system. What activates this inflammasome assemblage? Here is what the authors state:

“The NLRP3 inflammasome is especially relevant to aging as it can get activated in response to structurally diverse damage-associated molecular patterns (DAMPs) such as extracellular ATP, excess glucose, ceramides, amyloids, urate and cholesterol crystals, all of which increase with age. Interestingly, reduction of NLRP3-mediated (inflammasome) inflammation prevents age-related insulin-resistance, bone loss, cognitive decline and frailty. NLRP3 (inflammasome formation) is a major driver of age-related inflammation and therefore dietary or pharmacological approaches to lower aberrant inflammasome activation holds promise in reducing multiple chronic diseases of age and may enhance healthspan.”

 

Bottom Line: If you read the last sentence above this one, your next question is are there any dietary choices that can lower inflammasome activation? Well yes there are, and would you guess that it a whole-food, plant-based, unprocessed polyphenol rich diet? Would you also guess that that diet is associated with a better healthspan and lifespan? If so, why wouldn’t you eat that way? If you don’t, you are inviting illness, accelerated aging, a shorter health span, a shorter lifespan and living sicker is no fun.

Results: In hierarchical linear regression, foods investigated as polyphenolic modulators of DNA methylation (green tea, oolong tea, turmeric, rosemary, garlic, berries) categorized in the original study as methyl adaptogens showed significant linear associations with epigenetic (environmentally induced) age change (B = -1.21, CI = [-2.80, -0.08]), after controlling for baseline epigenetic age acceleration and weight changes. Although the intervention group lost significantly more weight than the control group, these changes were not associated with epigenetic age changes in the regression model. These findings suggest that consuming foods categorized as methyl adaptogens may reduce markers of epigenetic aging (inflammaging).         https://pmc.ncbi.nlm.nih.gov/articles/PMC12074822/

 

While this was a ‘flexitarian’ dietary approach, what are the primary foods these studies found produced the greatest benefits? If you read the study, you will find it was: “Colorful vegetables and fruit were the most frequently consumed food groups.”  If you want more info, you can read ‘Younger You’ by Kara Fitzgerald…an excellent book and she was significantly ahead of the research!!

By Mark Smith February 2, 2026
New Title
By Mark Smith January 26, 2026
New Title
By Mark Smith January 19, 2026
New Title
By Mark Smith January 12, 2026
New Title
By Mark Smith January 5, 2026
Health News Update: Happy New Year 2026! 1.5.26 Hey there everyone: Here is some news you can use to help you age optimally. I have written before about circadian rhythms and meal timing where it has been shown that eTRF (early time restricted feeding) has many benefits. But what happens as we age and shift our mealtimes away from our natural circadian clocks? Here are some snippets from this paper: “Chrononutrition, the study of the timing of eating, has emerged as a modifiable risk factor for adverse health outcomes The role of eating schedules is biologically relevant as dietary intake acts as an environmental cue influencing the circadian clocks of peripheral metabolic tissues and therefore can contribute to circadian misalignment and internal desynchrony 2 , 10 . The emerging evidence largely suggests that later mealtimes, particularly eating during the biological evening, is detrimental to health, Physical and psychological illnesses, including fatigue, oral health problems, depression, anxiety, and multimorbidity, are primarily associated with later breakfast. Later breakfast timing is also associated with increased mortality Importantly, eating breakfast later with aging was linked to a higher risk of death” https://www.nature.com/articles/s43856-025-01035-x meal timing important for health Bottom Line: While this paper focuses on the elderly, it is certainly applicable to all of us. I have seen significant health benefits when people adopt eTRF patters…from better digestion to weight loss, to better sleep, to more energy! Here are two links to my earlier blogs for the info on when to eat for optimal health: https://www.richmondchironeuro.com/health-news-update-when-you-eat-is-critical-to-long-term-health https://www.richmondchironeuro.com/health-news-update-when-we-eat-is-as-critical-as-what-we-eat
By Mark Smith December 29, 2025
Health News Update: Health is Your Most Valuable Asset 12.29.2025 Hello again everyone: This blog is a follow up to last week’s Christmas wishes, because it is my sincere wish for each of you that you fully embrace a healthy lifestyle for 2026 and beyond. Health is built on many components, and if you were to choose just one to get started, it would be to seriously upgrade your food choices, which specifically means a whole food, unprocessed or minimally processed (home cooking), plant-based food plan. Why? As you have heard me say, over and over, that inflammation will cause, perpetuate, and/or aggravate ALL chronic conditions and diseases plus it makes us susceptible to acute illness such as infections (flu, mono, Covid, etc.). As noted in the Journal of the American Medical Association (1), the Standard American Diet (SAD) is the leading cause of death and disability in our country and many others. It used to be that the leading causes of death were Communicable Diseases, i.e., infections. Today, the leading causes of death are Non-Communicable Diseases (NCD’s) such as heart disease, cancer, high blood pressure, stroke, diabetes, dementia…these chronic degenerative diseases are responsible for over 70% of all deaths worldwide. (2) Additionally, while we are living longer, we are living sicker. This means that our healthspan is about 10 to 15 years shorter than our lifespan…this is a deplorable condition that I have seen so many suffer through with progressive disability, suffering, and an early and unpleasant death spiral. At this moment, about 40% of us have multiple chronic health conditions while nearly 60% are burdened with at least one chronic health diagnosis…and this situation has only been forecasted to worsen significantly. (3,4) The tragedy is that this situation is largely preventable. You already know that food is the leading cause of death and disability…so what foods are they talking about? The researchers are talking about the Standard American Diet, also known as SAD…which is unfortunately a very fitting abbreviation. The SAD is notable for a high consumption of processed and ultra-processed foods, added sugars, saturated fats, refined carbohydrates, processed meats, red meat, additives, colorings, flavor enhancers, sugary drinks, higher pesticide and chemical burdens, and refined grains…and lacking in clean sources of vegetables, fruits, whole grains, nuts, seeds, legumes, and leaner protein sources. (5) The SAD diet is notable for high energy density and low nutrient density...a recipe for illness. All cellular processed require nutrition, not just calories. No single food has all of the nutrients, vitamins, minerals, phytonutrients, fiber, protein, fat, and carbohydrates that we need to thrive and remain robust and resilient. Consuming a diet that results in insufficiency, deficiency, or an excess of nutrients will eventually lead to some type of illness, disease, or condition as well as predispose you to becoming chronically inflamed, ill, or just sick. The SAD diet has been linked to many chronic diseases primarily because it leads to uncontrolled, chronic, background inflammation that drives health degeneration. Current research states that on average both children and adults consume 60% of their daily caloric intake from ultra-processed foods and only 10% of us meet the daily requirements for recommended fruit and vegetable intake (5, 6, 7) and 73% of our food supply is ultra-processed. Additionally, many studies have revealed that this type of ‘food’ is directly linked to many diseases and conditions and has been categorized as a high inflammatory potential diet. (8) An inflammatory dietary pattern will cause, perpetuate, and/or aggravate all of the leading causes of death and disability…or as some research puts it, “The chronic inflammatory state significantly contributes to the development and progression of many noncommunicable disease processes, including cancer, cardiovascular disease, and neurocognitive decline.” (13) On the flip side, a diet that consists of minimally processed, whole food, plant-based sources of nutrient dense, low inflammatory potential, and calorically appropriate foods is associated with fewer diseases, better health, less disability and an overall higher quality of life. It even helps when you are already not feeling well. (9,10,11,12,13,14) In my practice and clinical experience, without an optimal food plan, no amount of adjustments, vitamins, herbs, exercise, or stress reduction will work nearly as well as they should, if at all. Additionally, you should know that if you would like to experience healthy aging, an anti-inflammatory food upgrade is essential…and this includes both physically and cognitively. By now, I hope you are at least curious about consuming an anti-inflammatory, unprocessed, clean, whole food plant-based dietary lifestyle. This is not a sprint…we are all in it for the long haul and slow and steady (consistency) wins the race. Invest in yourself by taking classes in how to create your optimal food plan. I have recently taken several courses and gotten a lot out of them and upgraded our foods even more. (15,16,17,18,19) Undoubtably there are more classes out there…let me know what you find! Remember, you can start slowly and gradually work your way into this upgrade/shift. For example, in week one, you can start with 2 or 3 plant based lunches and next week add a breakfast, and so on. You can reduce your animal foods gradually at a pace you can be comfortable with. Just start…go plant-based and see what happens…you have nothing to lose (except some unwanted pounds and inflammation) and everything to gain. Part of being a good steward and tending your Temple is realizing that food is an essential part of our worship. We would never put diesel into our gas tank, nor should we put ultra-processed ‘food like things’ into our Temple. Now that you know this, what will you choose to do? So, this is my New Years wish for you and yours: freedom from disability, illness, and disease, a massive recovery if you need it, and the feeling of vibrant health always. Thank you for your time and attention…all the best for 2026! References: 1. https://jamanetwork.com/journals/jama/fullarticle/2678018 (see Figure 2) 2. https://pmc.ncbi.nlm.nih.gov/articles/PMC10830426/ 3. https://chronicdisease.org/wp-content/uploads/2022/04/FS_ChronicDiseaseCommentary2022FINAL.pdf 4. https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1082183/full 5. https://www.medicalnewstoday.com/articles/western-diet 6. https://foodtank.com/news/2022/11/database-indicates-u-s-food-supply-is-73-percent-ultra-processed/ 7. https://www.medicalnewstoday.com/articles/overall-diet-quality-may-be-more-important-than-how-much-ultra-processed-foods-you-eat#Why-ultra-processed-foods-are-unhealthy 8. https://www.medicalnewstoday.com/articles/overall-diet-quality-may-be-more-important-than-how-much-ultra-processed-foods-you-eat#How-to-have-a-more-healthy-diet 9. https://health.unl.edu/health-benefits-anti-inflammatory-diet-10-foods-eat-and-6-avoid/ 10. https://www.hopkinsmedicine.org/health/wellness-and-prevention/anti-inflammatory-diet 11. https://www.henryford.com/blog/2020/07/health-benefits-antiinflammatory-diet 12. https://www.health.harvard.edu/staying-healthy/quick-start-guide-to-an-antiinflammation-diet 13. https://www.ncbi.nlm.nih.gov/books/NBK597377/ 14. https://pmc.ncbi.nlm.nih.gov/articles/PMC8389628/ 15. https://simplyplantbasedkitchen.com/ 16. https://thriving.foodrevolution.org/join/?frn_source=blog&frn_medium=link&frn_campaign=ppt&frn_content=menu 17. https://hellonutritarian.com/nutritarian-power-prep-program/ 18. https://cookingcourse.forksoverknives.com/ 19. https://www.drfuhrman.com/blog/210/beginners-guide
By Mark Smith December 22, 2025
Health News Update: Tending Your Temple 12.22.25 Hello everyone, and Merry Christmas to you! Health Update: Predictable Crisis Hello everyone: As we celebrate this Holy time and the start of a new year, I want to just speak to you heart to heart. Most of us know that our physical body has been deemed to be the Temple for us to experience this worldly life. Additionally, we are meant to be stewards and caretakers of this awesomely wrought and magnificent Temple. While this may mean different things to each of us, most of us agree that taking care of the Temple involves a health promoting lifestyle. From interviewing thousands of patients, I have seen that deep within each of us there is a feeling or a knowingness of how well we are tending our Temple. And what emerges from these discussions is that most of us have never been taught or shown or educated on the concept of the need to be good stewards and how to do that. For me as a healthcare practitioner, science allows me to peer into God’s creation and be filled with awe and wonder. And yet as great as science has gotten at treating the leading causes of death and disability, it seems to have forgotten that recovery depends upon our innate healing abilities which in turn depends upon our food choices. Chronic unhealthy food choices really do affect your quality of life as well as what diseases or disabilities you may get, along with your ability to recover from them or to even prevent them. On top of that, science now recognizes how food choices have shifted over time and how this is leading to environmental destruction and contributing to climate change. The old saying “Let Food Be Thy Medicine” now applies to each of us as well as the planet. We Have Created a Predictable Crisis Nowhere can this be as easily seen as with the mismatch we are creating between what our body needs and what we are feeding it. Poor food choices, lack of physical activity, and stress drive the leading causes of death and disability. These facts are undeniable, and science has verified this many times over. What do we think will happen when we put diesel fuel into the gas tank? What are we thinking when we put drive-through into a Holy Temple? Each of us can do better and we all should try every day. Poor nutrition is now known to be the leading cause of death and chronic illness…and thus massive and needless suffering. Today, 8 out of 10 of the causes of death and disability are chronic inflammatory degenerative illnesses that are caused, perpetuated, aggravated, and sustained by food choices. Our societies current reactive approach to health care, without improving the underlying health of the patient, is expensive and has led us to the era of predictable yet unnecessary chronic illness, death, and disability. I am truly fortunate to have witnessed people recover their health through simple dietary upgrades. These people were patient, committed, and took one small step at a time until they had transformed their health, their kitchen, and in many cases, they assisted in the transformation of their entire family to better health and wellbeing. This transformation is available to you, too. If you have a chronic health condition, or want to avoid one, you have nothing to lose and everything to gain by going predominantly plant based. Go into this upgrade with a 100% commitment for 6 months and see how it goes. Don’t you owe it to yourself to live a life congruent with your true nature? Shouldn’t we have the self-respect to make the best choices as to how we tend our Temple? Simply by making your food choices compatible with your nature, it is possible for you to massively improve your health and simultaneously feel better about your stewardship of the Temple and the planet that sustains it. Consider for a moment, how good it will feel to live in alignment with your true Nature. If you can imagine that, then you can achieve it! All of us here at Richmond Chiropractic Neurology wish everyone a healthy, safe, happy, and loving Holy Day and Blessed New Year!
By Mark Smith December 15, 2025
New Title
By Mark Smith December 8, 2025
New Title
More Posts