Health New Update: Food, Inflammation, & Chronic Diseases

Mark Smith • November 10, 2025

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Health New Update: Food, Inflammation, & Chronic Diseases                                  11.10.25

Hello everyone: The research and science continue to reinforce the connection between inflammation and virtually all chronic health conditions, from heart attack, to cancer, to dementia, to everyday fatigue, depression, anxiety, insomnia, as well as aches and pains.

 

“Inflammation is now widely believed to be a cause of atherosclerosis [1,2]. Moreover, inflammation is an underlying pathophysiological mechanism in many other chronic diseases, including obesity [3] and type 2 diabetes mellitus [4], in addition to cardiovascular disease (CVD) [5]. Multiple factors contribute to this inflammatory process, including age, sex, physical activity, smoking, the use of certain medications, and diet [6]. Therefore, lifestyle and diet have a significant impact on health which is based, at least in part, on its association with inflammation [7,8].

 

Diet is a major determinant of inflammation, and a number of markers can be used to assess the inflammation in human nutrition studies [9,10]. Pro-inflammatory biomarkers, such as tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), or cell adhesion molecules have been used as indices of the effect of dietary patterns on low-grade inflammatory status [11–15]. In fact, the inverse association of a Mediterranean-style diet with major chronic disease is partially attributed to the anti-inflammatory properties of some of their foods such as fruits, extra-virgin olive oil, red wine, or nuts [16,17], and some of their bioactive components, such as polyphenols [18]. In contrast, certain components of diet, such as red meat and processed foods, are considered to be pro-inflammatory stimulants [19,20].”

 

https://www.academia.edu/48088815/The_Role_of_Dietary_Inflammatory_Index_in_Cardiovascular_Disease_Metabolic_Syndrome_and_Mortality?email_work_card=view-paper

 

Bottom Line: Just looking at the diet advice that is offered on all types of media can leave most of us feeling confused and frustrated. However, there is a growing scientific consensus of what makes a healthy diet, but you won’t find this information easily…there are just too many financial interests that would be negatively impacted if we all ate properly.

 

Imagine lowering your cancer risk by 25% (which means 80,000 cancer cases in the U.S. per year are diet related), or lowering your risk of cardiovascular disease by 90%, and doing this just by consuming a delicious unprocessed, whole-food, predominantly plant-based food plan. This food plan is called the Green Mediterranean diet and is easy to adopt.

 

If you are not a good chef, becoming one can save your life…plus it can be a fun, relaxing, enjoyable and social activity that not only saves money but supports your health and wellbeing. Invest in some cookbooks and watch your health savings account grow to create a safer future.

 

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Health News Update: Pesticides, Cancer & Why Go Organic 6.29.26 Hello everyone: Slowly but surely, despite the health and food industries downplaying the risks, evidence is emerging that the long-term consumption of trace amounts of toxic chemicals can add up to some serious health consequences. “Our process-based model, encompassing 31 key pesticide active ingredients, together with an innovative stratification of cancer cases by developmental lineage, reveals a robust spatial association between environmental pesticide exposure risk and cancer incidence. In pesticide-associated cancer hotspots, exposomic profiling of liver tissue—a primary target of chemical carcinogens—uncovers a distinct transcriptomic signature of pesticide exposure, implicating a non-genotoxic mode of action that disrupts core regulatory circuitries sustaining cell identity. Collectively, these findings strongly support a mechanistic link between pesticide exposure and cancer, challenging assumptions of human non-carcinogenicity derived from reductionist experimental models. This study redefines the exposome as a lineage-conditioned, mechanistically tractable framework and shows how complex pesticide mixtures can contribute to carcinogenic trajectories, with profound and far-reaching implications for global health policy and socio-ecological equity.” https://www.nature.com/articles/s44360-026-00087-0 pesticide exposure & cancer risks Bottom Line: Whenever possible, purchase your food from organic sources including local farmers that use regenerative and organic practices. Not all foods need to be organic, and to decide which ones absolutely need to be, you can access the Environmental Working Group’s yearly list of the Dirty Dozen foods that are the highest in pesticide residues. This will also include the Clean 15 foods that do not need to be organic as they are usually grown without or with very low pesticide levels. https://www.ewg.org/foodnews/dirty-dozen.php dirty dozen food guide Additionally, high quality nutrients support the natural detox processes our bodies use to get rid of any and all toxins. When we consume the Standard American Diet or Westernized Diet, we are low in the nutrients and co-factors needed to support optimal detox cleansing. So always start with food upgrades as they will carry your upgrade the farthest. Remember that most chronic health conditions start 20 years before you even notice them creeping up or becoming diagnosed. What you do now is creating your future. It used to be said that you are what you eat. Another way to say that is we become what we eat…so please take good care and make sure you always put high grade fuel into your Temple.
By Mark Smith June 22, 2026
Health news Update: High Fat Diets Promote Inflammation and Illness 6.22.26 Hello again: This news has been slow to surface with the popularity of keto and paleo dietary trends, but the following information is what is known about the typical Standard American Diet, also known as the Western Diet. “Conclusion : HFD-associated low-grade inflammation results from overlapping effects of dysbiosis and high fat intake, with crosstalk between microbiota and fat-driven inflammatory processes independent of gut flora involving multiple mechanisms. For this reason, it is difficult to determine what occurs first, thus, HFD-driven dysbiosis and HFD-related inflammation should be considered partially independent but closely correlated mechanisms.” https://pmc.ncbi.nlm.nih.gov/articles/PMC8619527/ High fat promotes inflammation Bottom Line: As you all know by now, inflammation will cause, perpetuate, and/or aggravate every known illness or condition, including aging. The next logical question is what to eat? The answer is the Green Mediterranean food plan…which essentially going vegan but allowing some animal-based foods no more than 3 times per week. This takes some planning but is most easily achieved by using a ‘crowding out’ method. This is simply accomplished by including more and more unprocessed, whole plant-based foods in place of processed or fatty foods and naturally reducing those less than healthy items. Below is some more information to help you make the switch…knowing that you can improve your day-to-day nutrition by making small consistent upgraded choices is critical. Upgrades to improve your health path do not usually arise from one big resolution but from those small individual choices made every day…and these add up to some major improvements over several months and longer. “The gut microbiota is responsible for recovering energy from food, providing hosts with vitamins, and providing a barrier function against exogenous pathogens. In addition, it is involved in maintaining the integrity of the intestinal epithelial barrier, crucial for the functional maturation of the gut immune system. The Western diet (WD)—an unhealthy diet with high consumption of fats—can be broadly characterized by overeating, frequent snacking, and a prolonged postprandial state. The term WD is commonly known and intuitively understood. However, the strict digital expression of nutrient ratios is not precisely defined. Based on the US data for 1908–1989, the calory intake available from fats increased from 32% to 45%. Besides the metabolic aspects (hyperinsulinemia, insulin resistance, dyslipidemia, sympathetic nervous system and renin-angiotensin system overstimulation, and oxidative stress), the consequences of excessive fat consumption (high-fat diet—HFD) comprise dysbiosis, gut barrier dysfunction, increased intestinal permeability, and leakage of toxic bacterial metabolites into the circulation. These can strongly contribute to the development of low-grade systemic inflammation.”
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Health News Update: Meal Timing Makes a Significant Difference 6.15.26 Hey there everyone: There are more and more papers coming out about meal timing and they pretty much all point to the same conclusion: “These study results are observational, so not proof of causation, but it fits broader chrononutrition science showing that aligning meals with daytime circadian biology supports metabolic and overall health.” — Monique Richard, MS, RDN, LDN https://www.medicalnewstoday.com/articles/eating-breakfast-late-linked-biological-aging-depression-oral-health?utm_source=Sailthru%20Email&utm_medium=Email&utm_campaign=sundaysupplement&utm_content=2025-09-14&apid=32362300&rvid=24561ae4b347411c6ae1874dad579a0aedec4a5e471e9b3b5a21dc0826faa6b9#Eating-breakfast-later-in-the-day-linked-to-several-health-issues eating breakfast important for long term health Bottom Line: To achieve a meal timing pattern that is in harmony with your circadian clock, consider what the authors provided: Anchor the Day Early: Aim to eat breakfast within one to two hours of waking, most days. A simple pattern like breakfast: 7–8 a.m., lunch: noon–1 p.m., dinner: 5–7 p.m. works for many families and individuals, allowing for possible snacks as necessary, keeping a consistent window of sleep and fasting open ~10–12 hours, and try to avoid snacking two to three hours before bed. Front-Load Protein: Target ~25–30 g protein at breakfast (e.g., Greek yogurt + nuts + berries ; eggs + beans + veg; protein-fortified oatmeal ). Distributing protein across meals supports muscle function, brain health, satiation, and numerous other functions. Eat Early and Evenly: A protein-strong breakfast, a steady midday meal, and a light, timely dinner, hydration in between, coupled with laughter and loved ones. This schedule pretty much is defined as eTRF, or early Time Restricted Feeding, which is known to have multiple benefits including weight loss and management, blood sugar balancing, improving sleep, and more.
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