Covid-19 & Health Update: Inflammation Clock can Reveal Biological Age

RVAchironeuro • August 19, 2021

Hey there everyone:

As you know, inflammation causes, aggravates, or perpetuates virtually every human illness. On top of that, inflammation is primarily an immune event, i.e., the immune system controls, coordinates and regulates virtually all the inflammatory processes that occur within us. Scientists are beginning to look at our inflammatory burden as one of the primary drivers of aging that can be measured. The more our non-purposeful inflammation is under control and well managed, the healthier we are and the longer we live. Purposeful inflammation is part of the process that keeps us healthy, and it waxes and wanes as needed and does not linger. For example, if we get a cut on our hand, it will turn red, get warm, swell, and hurt…the classical signs of purposeful inflammation because inflammation is the first component of all healing and repair. This inflammation will usually peak in several days and then gradually fade as the repair process progresses until things are resolved.

Non-purposeful inflammation is chronic and lingering long after the healing process has finished. It turns out that diet is a potent source of chronic inflammation, as well as background infections, toxin exposure, chronic stress chemistry, gut and digestive issues, hormone imbalances and more. It is this chronic low to moderate grade inflammation that becomes degenerative over time and leads to chronic illness. Here are some quotes from the two links below that are about the same paper:

“A new type of age ‘clock’ can assess chronic inflammation to predict whether someone is at risk of developing age-related disorders such as cardiovascular and neurodegenerative disease. The clock measures ‘biological age’, which takes health into consideration and can be higher or lower than a person’s chronological age.

  The inflammatory ageing clock (iAge), reported on 12 July in Nature Aging 1 , is one of the first tools of its kind to use inflammation to assess health…. The researchers who developed iAge hope that, because inflammation is treatable, the tool could help doctors determine who would benefit from intervention — potentially extending the number of years a person lives in good health.”

The study “is a further reinforcement of the fact that the immune system is critical, not only for predicting unhealthy ageing, but also as a mechanism driving it”, says Vishwa Deep Dixit, an immunobiologist at Yale School of Medicine in New Haven, Connecticut, who was not involved in the work.

“iAge is based on the idea that as a person ages, their body experiences chronic, systemic inflammation because their cells become damaged and emit inflammation-causing molecules. This ultimately leads to wear and tear on their tissues and organs. People who have a healthy immune system will be able to neutralize this inflammation to some extent, whereas others will age faster.

Bottom Line: One of the key drivers of inflammation and aging is once again based on our food choices. All you have to do is to Google ‘anti-inflammatory diet’ to get thousands of hits. Read just a few of these and it becomes pretty clear what we all need to do: consume organic, unprocessed whole foods and avoid the rest.

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Health News Update: Happy New Year 2026! 1.5.26 Hey there everyone: Here is some news you can use to help you age optimally. I have written before about circadian rhythms and meal timing where it has been shown that eTRF (early time restricted feeding) has many benefits. But what happens as we age and shift our mealtimes away from our natural circadian clocks? Here are some snippets from this paper: “Chrononutrition, the study of the timing of eating, has emerged as a modifiable risk factor for adverse health outcomes The role of eating schedules is biologically relevant as dietary intake acts as an environmental cue influencing the circadian clocks of peripheral metabolic tissues and therefore can contribute to circadian misalignment and internal desynchrony 2 , 10 . The emerging evidence largely suggests that later mealtimes, particularly eating during the biological evening, is detrimental to health, Physical and psychological illnesses, including fatigue, oral health problems, depression, anxiety, and multimorbidity, are primarily associated with later breakfast. Later breakfast timing is also associated with increased mortality Importantly, eating breakfast later with aging was linked to a higher risk of death” https://www.nature.com/articles/s43856-025-01035-x meal timing important for health Bottom Line: While this paper focuses on the elderly, it is certainly applicable to all of us. I have seen significant health benefits when people adopt eTRF patters…from better digestion to weight loss, to better sleep, to more energy! Here are two links to my earlier blogs for the info on when to eat for optimal health: https://www.richmondchironeuro.com/health-news-update-when-you-eat-is-critical-to-long-term-health https://www.richmondchironeuro.com/health-news-update-when-we-eat-is-as-critical-as-what-we-eat
By Mark Smith December 29, 2025
Health News Update: Health is Your Most Valuable Asset 12.29.2025 Hello again everyone: This blog is a follow up to last week’s Christmas wishes, because it is my sincere wish for each of you that you fully embrace a healthy lifestyle for 2026 and beyond. Health is built on many components, and if you were to choose just one to get started, it would be to seriously upgrade your food choices, which specifically means a whole food, unprocessed or minimally processed (home cooking), plant-based food plan. Why? As you have heard me say, over and over, that inflammation will cause, perpetuate, and/or aggravate ALL chronic conditions and diseases plus it makes us susceptible to acute illness such as infections (flu, mono, Covid, etc.). As noted in the Journal of the American Medical Association (1), the Standard American Diet (SAD) is the leading cause of death and disability in our country and many others. It used to be that the leading causes of death were Communicable Diseases, i.e., infections. Today, the leading causes of death are Non-Communicable Diseases (NCD’s) such as heart disease, cancer, high blood pressure, stroke, diabetes, dementia…these chronic degenerative diseases are responsible for over 70% of all deaths worldwide. (2) Additionally, while we are living longer, we are living sicker. This means that our healthspan is about 10 to 15 years shorter than our lifespan…this is a deplorable condition that I have seen so many suffer through with progressive disability, suffering, and an early and unpleasant death spiral. At this moment, about 40% of us have multiple chronic health conditions while nearly 60% are burdened with at least one chronic health diagnosis…and this situation has only been forecasted to worsen significantly. (3,4) The tragedy is that this situation is largely preventable. You already know that food is the leading cause of death and disability…so what foods are they talking about? The researchers are talking about the Standard American Diet, also known as SAD…which is unfortunately a very fitting abbreviation. The SAD is notable for a high consumption of processed and ultra-processed foods, added sugars, saturated fats, refined carbohydrates, processed meats, red meat, additives, colorings, flavor enhancers, sugary drinks, higher pesticide and chemical burdens, and refined grains…and lacking in clean sources of vegetables, fruits, whole grains, nuts, seeds, legumes, and leaner protein sources. (5) The SAD diet is notable for high energy density and low nutrient density...a recipe for illness. All cellular processed require nutrition, not just calories. No single food has all of the nutrients, vitamins, minerals, phytonutrients, fiber, protein, fat, and carbohydrates that we need to thrive and remain robust and resilient. Consuming a diet that results in insufficiency, deficiency, or an excess of nutrients will eventually lead to some type of illness, disease, or condition as well as predispose you to becoming chronically inflamed, ill, or just sick. The SAD diet has been linked to many chronic diseases primarily because it leads to uncontrolled, chronic, background inflammation that drives health degeneration. Current research states that on average both children and adults consume 60% of their daily caloric intake from ultra-processed foods and only 10% of us meet the daily requirements for recommended fruit and vegetable intake (5, 6, 7) and 73% of our food supply is ultra-processed. Additionally, many studies have revealed that this type of ‘food’ is directly linked to many diseases and conditions and has been categorized as a high inflammatory potential diet. (8) An inflammatory dietary pattern will cause, perpetuate, and/or aggravate all of the leading causes of death and disability…or as some research puts it, “The chronic inflammatory state significantly contributes to the development and progression of many noncommunicable disease processes, including cancer, cardiovascular disease, and neurocognitive decline.” (13) On the flip side, a diet that consists of minimally processed, whole food, plant-based sources of nutrient dense, low inflammatory potential, and calorically appropriate foods is associated with fewer diseases, better health, less disability and an overall higher quality of life. It even helps when you are already not feeling well. (9,10,11,12,13,14) In my practice and clinical experience, without an optimal food plan, no amount of adjustments, vitamins, herbs, exercise, or stress reduction will work nearly as well as they should, if at all. Additionally, you should know that if you would like to experience healthy aging, an anti-inflammatory food upgrade is essential…and this includes both physically and cognitively. By now, I hope you are at least curious about consuming an anti-inflammatory, unprocessed, clean, whole food plant-based dietary lifestyle. This is not a sprint…we are all in it for the long haul and slow and steady (consistency) wins the race. Invest in yourself by taking classes in how to create your optimal food plan. I have recently taken several courses and gotten a lot out of them and upgraded our foods even more. (15,16,17,18,19) Undoubtably there are more classes out there…let me know what you find! Remember, you can start slowly and gradually work your way into this upgrade/shift. For example, in week one, you can start with 2 or 3 plant based lunches and next week add a breakfast, and so on. You can reduce your animal foods gradually at a pace you can be comfortable with. Just start…go plant-based and see what happens…you have nothing to lose (except some unwanted pounds and inflammation) and everything to gain. Part of being a good steward and tending your Temple is realizing that food is an essential part of our worship. We would never put diesel into our gas tank, nor should we put ultra-processed ‘food like things’ into our Temple. Now that you know this, what will you choose to do? So, this is my New Years wish for you and yours: freedom from disability, illness, and disease, a massive recovery if you need it, and the feeling of vibrant health always. Thank you for your time and attention…all the best for 2026! References: 1. https://jamanetwork.com/journals/jama/fullarticle/2678018 (see Figure 2) 2. https://pmc.ncbi.nlm.nih.gov/articles/PMC10830426/ 3. https://chronicdisease.org/wp-content/uploads/2022/04/FS_ChronicDiseaseCommentary2022FINAL.pdf 4. https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1082183/full 5. https://www.medicalnewstoday.com/articles/western-diet 6. https://foodtank.com/news/2022/11/database-indicates-u-s-food-supply-is-73-percent-ultra-processed/ 7. https://www.medicalnewstoday.com/articles/overall-diet-quality-may-be-more-important-than-how-much-ultra-processed-foods-you-eat#Why-ultra-processed-foods-are-unhealthy 8. https://www.medicalnewstoday.com/articles/overall-diet-quality-may-be-more-important-than-how-much-ultra-processed-foods-you-eat#How-to-have-a-more-healthy-diet 9. https://health.unl.edu/health-benefits-anti-inflammatory-diet-10-foods-eat-and-6-avoid/ 10. https://www.hopkinsmedicine.org/health/wellness-and-prevention/anti-inflammatory-diet 11. https://www.henryford.com/blog/2020/07/health-benefits-antiinflammatory-diet 12. https://www.health.harvard.edu/staying-healthy/quick-start-guide-to-an-antiinflammation-diet 13. https://www.ncbi.nlm.nih.gov/books/NBK597377/ 14. https://pmc.ncbi.nlm.nih.gov/articles/PMC8389628/ 15. https://simplyplantbasedkitchen.com/ 16. https://thriving.foodrevolution.org/join/?frn_source=blog&frn_medium=link&frn_campaign=ppt&frn_content=menu 17. https://hellonutritarian.com/nutritarian-power-prep-program/ 18. https://cookingcourse.forksoverknives.com/ 19. https://www.drfuhrman.com/blog/210/beginners-guide
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