Health Update: The Steep Costs of Leaky Gut

Mark Smith • January 8, 2024

Hello again everyone:

 

I was really pleased to read the interview in the link I posted below. This is a great condensed discussion of how the S.A.D. (the Standard American Diet) can disrupt the gut barrier and microbiome and contribute to the development of inflammation and thus become a major driver of illness. I would strongly recommend that you take the 8 to 10 minutes it takes to read this interview (it is only 3 pages long with large font print). Here are the highlights from the article link below:


·        When the gut barrier is disrupted, it becomes ‘leaky’ or hyperpermeable.

·        ‘Leaky gut’ leads to inflammatory immune system activation as 70% of our immune system resides in the intestinal tract.

·        This situation can be very symptomatic but is often asymptomatic.

·        Many things cause or make it worse, including: acrolein (food toxin), aging, alcohol, antacid drugs, antibiotics, burn injury, chemotherapy, circadian rhythm disruption, corticosteroids, emulsifiers (food additives), strenuous exercise (≥ 2 hours) at 60% Vo2 max, starvation, fructose, fructans, gliadin (wheat protein), high-fat diet, high-salt diet, high-sugar diet, hyperglycemia, low-fiber diet, nonsteroidal anti-inflammatory drugs, pesticide, proinflammatory cytokines, psychological stress, radiation, sleep deprivation, smoking, and sweeteners.

·        S.A.D food plans, also known as the Standard American Diet, are very low in fiber which is essential for gut health.

·        Many interventions have been shown to improve intestinal permeability. They include berberine, butyrate, caloric restriction and fasting, curcumin, dietary fiber (prebiotics), moderate exercise, fermented food, fish oilglutaminequercetin, probiotics, vagus nerve stimulation, vitamin D, and zinc.

·        It is important to emphasize a high-fiber diet with naturally fermented food, incorporating time-restricted eating, such as eating an early dinner and nothing else before bedtime, a moderate exercise routine, and gut-brain modulation with techniques such as acupuncture that can incorporate vagus nerve stimulation.

·        Limited safe precision supplementation can be discussed on an individual basis based on the patient's interest, additional testing, and other existing health conditions.

 

https://www.medscape.com/viewarticle/998125?ecd=mkm_ret_231119_mscpmrk_neuro_brain-diet_etid6069650&uac=428598BV&impID=6069650#vp_3


Bottom Line:

 

As you know, inflammation will cause, perpetuate, and or aggravate all known human illness or conditions. Paying attention to healing a hyperpermeable gut is foundational to optimizing your health and lowering a major driver of inflammation. This step is very often critical in the recovery of almost any chronic health condition. One thing that was not mentioned but that I have seen as critically important is that chewing adequately is an absolute necessity when it comes to restoring or improving leaky gut. Along with some of the above ideas, my new motto is Chew 22 as the first step in gut restoration and lowering your inflammatory burden. Another tip is to eat your food in a specific order to allow for better digestion: salad and non-starchy veggies first, then proteins and fats, and lastly starchy veggies and grains/carbs. Try just Chew 22 and eating your meals with this specific order and let me know if it assists your digestion and/or overall health. 

By Mark Smith March 23, 2026
Health News Update: How To Fight Inflammation and Chronic Disease 3.23.26 Hello again everyone: You might wonder why I keep focusing on food…so here are some of the reasons: food choices are the leading cause of death in the U.S. and spreading around the world. Poor food choices lead to inflammation which slowly destroy health. It is that simple, plain, and clear and backed by research. The next question: how do we fight back? Introduction The positive impact of food on health was postulated by the ancient Hippocrates, father of modern medicine with his famous quote: “Let food be thy medicine and medicine be thy food” [1]. In the 21st century, scientists have focused on the effect of nutritional habits in diseases. Nowadays, it is well documented that food plays a noteworthy role in the pathogenesis of chronic diseases namely cardiovascular diseases (CVD), metabolic syndrome, diabetes mellitus type II, and cancer [2–5], as it correlates with others with the lipid pattern, the blood pressure, and the endothelial function. The scientists examine the effect of nutritional habits on disease emergence and progression in both individual nutrient intake and dietary patterns models. Worldwide, two dietary patterns are usually compared—the Mediterranean diet (MD) and the Western diet (WD) [3,6]. The Mediterranean diet reflects the food culture of most Mediterranean countries based on olive oil consumption, seasonal fresh vegetables, cereals, and plants in balance with low consumption of meat [7]. The Western diet, on the contrary, is dominated by high-fat dairy products processed and red meat [8]. However, discordance in the different MD patterns and consumed food doses had been recognized. Without any doubt, those discrepancies could confine and restrict our knowledge on the health benefit mechanisms of the MD [9]. Due to the above, the medical community along with nutritionists and dieticians take a keen interest in MD and its traits [7]. https://www.academia.edu/45378994/biomedicines_Mediterranean_Diet_as_a_Tool_to_Combat_Inflammation_and_Chronic_Diseases_An_Overview?email_work_card=view-paper food choices can fight inflammation and chronic disease Bottom Line: This is a 2020 paper and since then literally hundreds of papers on the MD have emerged showing how the food plan lowers inflammation and the risk for developing multiple chronic illnesses. Even still, lots of research needs to be done to elucidate the many mechanisms of how food impacts our system and how to optimally individualize dietary recommendations. At this point, our best strategy to prevent and/or recover from any chronic condition is to eat as clean and natural as possible. It has become rather obvious that the further away from a natural diet we get, the sicker we become. On top of that, I have yet to see a full recovery from any health issue without the foundation of a predominantly plant-based, unprocessed, whole foods approach…which is why I keep posting about this subject. All the best to you and yours!
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