Health Update: Social Isolation and Loneliness Up Dementia Risk

RVAchironeuro • June 20, 2022

Hello again everyone:

  This is a topic that I covered before, however, it is really very relevant today because of how the pandemic has forced many of us into socially isolated situations. It turns out that…guess what…social isolation and loneliness result in an increased burden of inflammation.

“Social isolation was linked with lower volume in brain areas related to cognition and associated with a higher risk of subsequent dementia as well, a longitudinal study showed. Recent research has shown that  lonely older adults  who otherwise would be expected to have relatively low risk had a threefold greater risk of dementia than those who weren’t lonely.  Midlife loneliness  also has been tied to late-life dementia and Alzheimer’s disease. Few studies, however, have looked at social isolation separately from loneliness.

“There is a difference between social isolation, which is an objective state of low social connections, and loneliness, which is subjectively perceived social isolation,” said co-author Edmund Rolls, PhD, of the University of Warwick in England.

“Both have risks to health but using the extensive multi-modal data set from the U.K. Biobank and working in a multidisciplinary way linking computational sciences and neuroscience, we have been able to show that it is social isolation, rather than the feeling of loneliness, which is an independent risk factor for later dementia,” he noted.

“With the growing prevalence of social isolation and loneliness over the past decades, this has been a serious yet underappreciated public health problem,” Rolls added. “Now, in the shadow of the COVID-19 pandemic there are implications for social relationship interventions and care, particularly in the older population.”

“Through a systematic investigation of the associations between social isolation, chronic inflammation, and adult mortality by cause using a nationally representative, population-based sample, we find support for the hypothesis that lack of social embeddedness elevates mortality risk through physiological upregulation of chronic inflammation.”

Bottom Line:

Friends don’t let friends stay socially isolated…we connect with them and keep them engaged. We get together with them and arrange a diverse array of activities, from church to food shopping, to visiting, to hiking, pickleball, playing games, book clubs, or even asking for their help with a yard or other type of appropriate activity. As you know, inflammation will cause, perpetuate, or aggravate any type of ailment. As it turns out, social engagement is a potent anti-inflammatory medication!!! Who knew friendship could be so medicinal!!! Don’t stay isolated…and this applies to children who have excessive screen time and may not get outside or play much with others…for health’s sake get outside and get moving a bit…even a daily walk with a buddy or a walking meeting at work…just get together and do something…and the more fun it is, the better it will be!!

 

 

 

 

By Mark Smith March 23, 2026
Health News Update: How To Fight Inflammation and Chronic Disease 3.23.26 Hello again everyone: You might wonder why I keep focusing on food…so here are some of the reasons: food choices are the leading cause of death in the U.S. and spreading around the world. Poor food choices lead to inflammation which slowly destroy health. It is that simple, plain, and clear and backed by research. The next question: how do we fight back? Introduction The positive impact of food on health was postulated by the ancient Hippocrates, father of modern medicine with his famous quote: “Let food be thy medicine and medicine be thy food” [1]. In the 21st century, scientists have focused on the effect of nutritional habits in diseases. Nowadays, it is well documented that food plays a noteworthy role in the pathogenesis of chronic diseases namely cardiovascular diseases (CVD), metabolic syndrome, diabetes mellitus type II, and cancer [2–5], as it correlates with others with the lipid pattern, the blood pressure, and the endothelial function. The scientists examine the effect of nutritional habits on disease emergence and progression in both individual nutrient intake and dietary patterns models. Worldwide, two dietary patterns are usually compared—the Mediterranean diet (MD) and the Western diet (WD) [3,6]. The Mediterranean diet reflects the food culture of most Mediterranean countries based on olive oil consumption, seasonal fresh vegetables, cereals, and plants in balance with low consumption of meat [7]. The Western diet, on the contrary, is dominated by high-fat dairy products processed and red meat [8]. However, discordance in the different MD patterns and consumed food doses had been recognized. Without any doubt, those discrepancies could confine and restrict our knowledge on the health benefit mechanisms of the MD [9]. Due to the above, the medical community along with nutritionists and dieticians take a keen interest in MD and its traits [7]. https://www.academia.edu/45378994/biomedicines_Mediterranean_Diet_as_a_Tool_to_Combat_Inflammation_and_Chronic_Diseases_An_Overview?email_work_card=view-paper food choices can fight inflammation and chronic disease Bottom Line: This is a 2020 paper and since then literally hundreds of papers on the MD have emerged showing how the food plan lowers inflammation and the risk for developing multiple chronic illnesses. Even still, lots of research needs to be done to elucidate the many mechanisms of how food impacts our system and how to optimally individualize dietary recommendations. At this point, our best strategy to prevent and/or recover from any chronic condition is to eat as clean and natural as possible. It has become rather obvious that the further away from a natural diet we get, the sicker we become. On top of that, I have yet to see a full recovery from any health issue without the foundation of a predominantly plant-based, unprocessed, whole foods approach…which is why I keep posting about this subject. All the best to you and yours!
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