Health Update: Gut Microbiome a Key Driver of Depression

Mark Smith • September 18, 2023

Hello again everyone:

 

It has been known for a long time that how healthy the gut is can be reflected in different organs, including the brain. Here is more evidence that depression is directly tied to our gut health. In other words, if you have depression, pay attention to optimizing your gut health as a component of your mental health care.

 

"As we wait to establish causal influences through clinical trials, clinicians should advise patients suffering from mood disorders to modify their diet by increasing the intake of fresh fruits, vegetables, and whole grains, as these provide the required fuel/fiber to the gut microbiota for their enrichment, and more short-chain fatty acids are produced for the optimal functioning of the body," study investigator Najaf Amin, PhD, DSc, senior researcher, Nuffield Department of Population Health, Oxford University, United Kingdom, told Medscape Medical News.

 

"At the same time, patients should be advised to minimize the intake of sugars and processed foods, which are known to have an inverse impact on the gut microbiome and are associated with higher inflammation," she said.


https://www.medscape.com/viewarticle/991178?ecd=mkm_ret_230610_mscpmrk_neuro_brain-diet_etid5509107&uac=428598BV&impID=5509107


Bottom Line:

 

There are a lot of great books available that go into this topic in greater depth and width and lead to some solutions for all of us. One such book is by Emeran Mayer, MD, a noted authority on this subject and author of: The Mind Gut Connection. In this book, he reveals the science behind why going predominantly plant-based is an integral and necessary part of both restoring your microbiome and gut health as well as restoring an optimally healthy gut-brain axis.


If you have depression of any type, adding a plant-based food plan should be considered as a foundational strategy to be implemented as a component of your mental health care. For more information on this, consider a search using these key word pairs:


Depression microbiome

Depression inflammation

Depression gut-brain axis


Furthermore, if you are having only a partial or inadequate response to an anti-depressant medication, adding L-methylfolate to that protocol can help significantly. (Also fix your gut). Check with your prescribing physician:


https://www.medscape.com/viewarticle/992700?ecd=mkm_ret_230610_mscpmrk_neuro_brain-diet_etid5509107&uac=428598BV&impID=5509107


By Mark Smith March 23, 2026
Health News Update: How To Fight Inflammation and Chronic Disease 3.23.26 Hello again everyone: You might wonder why I keep focusing on food…so here are some of the reasons: food choices are the leading cause of death in the U.S. and spreading around the world. Poor food choices lead to inflammation which slowly destroy health. It is that simple, plain, and clear and backed by research. The next question: how do we fight back? Introduction The positive impact of food on health was postulated by the ancient Hippocrates, father of modern medicine with his famous quote: “Let food be thy medicine and medicine be thy food” [1]. In the 21st century, scientists have focused on the effect of nutritional habits in diseases. Nowadays, it is well documented that food plays a noteworthy role in the pathogenesis of chronic diseases namely cardiovascular diseases (CVD), metabolic syndrome, diabetes mellitus type II, and cancer [2–5], as it correlates with others with the lipid pattern, the blood pressure, and the endothelial function. The scientists examine the effect of nutritional habits on disease emergence and progression in both individual nutrient intake and dietary patterns models. Worldwide, two dietary patterns are usually compared—the Mediterranean diet (MD) and the Western diet (WD) [3,6]. The Mediterranean diet reflects the food culture of most Mediterranean countries based on olive oil consumption, seasonal fresh vegetables, cereals, and plants in balance with low consumption of meat [7]. The Western diet, on the contrary, is dominated by high-fat dairy products processed and red meat [8]. However, discordance in the different MD patterns and consumed food doses had been recognized. Without any doubt, those discrepancies could confine and restrict our knowledge on the health benefit mechanisms of the MD [9]. Due to the above, the medical community along with nutritionists and dieticians take a keen interest in MD and its traits [7]. https://www.academia.edu/45378994/biomedicines_Mediterranean_Diet_as_a_Tool_to_Combat_Inflammation_and_Chronic_Diseases_An_Overview?email_work_card=view-paper food choices can fight inflammation and chronic disease Bottom Line: This is a 2020 paper and since then literally hundreds of papers on the MD have emerged showing how the food plan lowers inflammation and the risk for developing multiple chronic illnesses. Even still, lots of research needs to be done to elucidate the many mechanisms of how food impacts our system and how to optimally individualize dietary recommendations. At this point, our best strategy to prevent and/or recover from any chronic condition is to eat as clean and natural as possible. It has become rather obvious that the further away from a natural diet we get, the sicker we become. On top of that, I have yet to see a full recovery from any health issue without the foundation of a predominantly plant-based, unprocessed, whole foods approach…which is why I keep posting about this subject. All the best to you and yours!
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