Health News Update: When You Eat is as Important as What You Eat

Mark Smith • January 27, 2025

Hello everyone:

 

By now you are aware that what we eat will shape our health, either good or bad. You also know that this has everything to do with the inflammatory potential of the overall dietary pattern. And did you know that WHEN you eat also shapes your total inflammatory burden significantly! This has to do with aligning your circadian rhythms. These rhythms optimize certain functions at certain times of the day…in all of us. A lifestyle that coordinates food intake with our circadian rhythms has significant benefits.


Studies in mice and humans have shown that TRE can help with weight loss and result in metabolic improvement. TRE can be categorized into various subtypes based on different time windows for restricting food intake. Early TRE (eTRE) means starting the first meal in the early morning (before 10:00 a.m.), while late TRE (lateTRE) involves limiting mealtimes to the afternoon or evening. Based on the duration of fasting time, eTRE includes formats such as 16:08, 14:10, and 18:06 (F:E). Studies on circadian rhythms have confirmed that the thermal effect, insulin sensitivity and ꞵ-cell (pancreas insulin) function are better in the morning. eTRE is now widely proposed to be more in line with the circadian rhythm than lateTRE. Furthermore, skipping breakfast and late eating have been linked to T2D (type 2 diabetes), MetS (Metabolic syndrome), and obesity in various studies, and they may influence gut microbiome composition.

 

eTRE (early Time Restricted Eating) resulted in improved FM (Fat Mass), abdominal obesity, inflammation, and blood pressure and prevented FFM (Fat Free Mass = muscles) loss compared with non-TRE, especially in the 16:08 F:E strategy. It also had better metabolic effects on body weight, FBG (Fasting Blood Glucose) and HOMA-IR (Insulin Resistance) than non-TRE or lateTRE. Adherence-related outcomes were not affected. eTRE appears to be an effective strategy for the early prevention and treatment of MetS (pre-diabetes, high cholesterol, inflammation) and sarcopenic (muscle loss) obesity.

 

Furthermore, we found that eTRE resulted in reduced abdominal fat measures, such as WC (Waist Circumference) and VFA (Visceral Adipose Tissue), reduced inflammatory states via the lowering, and improved metabolic markers…”

 

https://www.sciencedirect.com/science/article/abs/pii/S1871402124000134

 

Bottom Line:

 

Please notice that eTRF lowers inflammation. What the papers do not mention is the positive effects that eTRF has on immune function and longevity, which are also significant.

For most of us, the 14 hours of fasting and 10 hours of eating works very well and is very easily done.

 

 

By Mark Smith March 23, 2026
Health News Update: How To Fight Inflammation and Chronic Disease 3.23.26 Hello again everyone: You might wonder why I keep focusing on food…so here are some of the reasons: food choices are the leading cause of death in the U.S. and spreading around the world. Poor food choices lead to inflammation which slowly destroy health. It is that simple, plain, and clear and backed by research. The next question: how do we fight back? Introduction The positive impact of food on health was postulated by the ancient Hippocrates, father of modern medicine with his famous quote: “Let food be thy medicine and medicine be thy food” [1]. In the 21st century, scientists have focused on the effect of nutritional habits in diseases. Nowadays, it is well documented that food plays a noteworthy role in the pathogenesis of chronic diseases namely cardiovascular diseases (CVD), metabolic syndrome, diabetes mellitus type II, and cancer [2–5], as it correlates with others with the lipid pattern, the blood pressure, and the endothelial function. The scientists examine the effect of nutritional habits on disease emergence and progression in both individual nutrient intake and dietary patterns models. Worldwide, two dietary patterns are usually compared—the Mediterranean diet (MD) and the Western diet (WD) [3,6]. The Mediterranean diet reflects the food culture of most Mediterranean countries based on olive oil consumption, seasonal fresh vegetables, cereals, and plants in balance with low consumption of meat [7]. The Western diet, on the contrary, is dominated by high-fat dairy products processed and red meat [8]. However, discordance in the different MD patterns and consumed food doses had been recognized. Without any doubt, those discrepancies could confine and restrict our knowledge on the health benefit mechanisms of the MD [9]. Due to the above, the medical community along with nutritionists and dieticians take a keen interest in MD and its traits [7]. https://www.academia.edu/45378994/biomedicines_Mediterranean_Diet_as_a_Tool_to_Combat_Inflammation_and_Chronic_Diseases_An_Overview?email_work_card=view-paper food choices can fight inflammation and chronic disease Bottom Line: This is a 2020 paper and since then literally hundreds of papers on the MD have emerged showing how the food plan lowers inflammation and the risk for developing multiple chronic illnesses. Even still, lots of research needs to be done to elucidate the many mechanisms of how food impacts our system and how to optimally individualize dietary recommendations. At this point, our best strategy to prevent and/or recover from any chronic condition is to eat as clean and natural as possible. It has become rather obvious that the further away from a natural diet we get, the sicker we become. On top of that, I have yet to see a full recovery from any health issue without the foundation of a predominantly plant-based, unprocessed, whole foods approach…which is why I keep posting about this subject. All the best to you and yours!
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